Wednesday, May 25, 2016

2,3,7,8‐tetrachlorodivenzo‐p‐dioxin (TCDD) stimulates tumor progression in mice

The environmental pollutant 2,3,7,8‐tetrachlorodibenzo‐ρ‐dioxin (TCDD) is the prototype of a large number of nongenotoxic environmental carcinogens, dietary phytochemicals and endogenous metabolites that act via binding the aryl hydrocarbon receptor (AHR). However, the mechanism(s) of carcinogenesis by these compounds is still unclear. We confirmed that TCDD‐liganded AHR massively upregulates CYP1A1, CYP1A2 and CYP1B1 in many mammalian organs.

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