Monday, February 18, 2019

Parkinson's Researchers, Michael J. Fox Foundation Propose New Roadmap for Trials

A new roadmap for preclinical and clinical trials investigating compounds to treat and prevent Parkinson’s disease was proposed by a team of international academic and industry researchers, the Alpha-Synuclein Clinical Path Working Group, in conjunction with the Michael J. Fox Foundation for Parkinson’s Research.
The article, “A Proposed Roadmap for Parkinson’s Disease Proof of Concept Clinical Trials Investigating Compounds Targeting Alpha-Synuclein,” was published in the Journal of Parkinson’s Disease.
A global effort is underway to find interventional molecules that slow or stop Parkinson’s progression. These potential therapeutics focus on targeting the protein alpha-synuclein, a component of abnormal clumps — Lewy bodies — that are the pathological hallmark of Parkinson’s disease.
“With alpha-synuclein undoubtedly playing some role in Parkinson’s disease pathogenesis, and there being such a diverse portfolio of experimental therapies that target the protein, one can be optimistic and hope that one of the approaches will eventually be successful in slowing disease progression,” Patrik Brundin, MD, PhD, from the Van Andel Research Institute, Grand Rapids, Michigan, said in a press release.
In 2017, The Michael J. Fox Foundation convened the Alpha-Synuclein Clinical Path Working Group, made up of leaders in Parkinson’s research from academia and industry. This international group set out to expedite the discovery and development of therapeutics with recommendations on research and development for alpha-synuclein targeting therapies.

No comments:

Post a Comment