http://www.pnas.org/content/112/44/13699.abstract
Studies examining paternal exposure to diverse environmental stimuli
propose that epigenetic marks in germ cells, including
small noncoding RNAs such as microRNA
(miR), transmit experience-dependent information from parent to
offspring. However,
these nongenetic mechanisms of
transgenerational inheritance are poorly understood, specifically how
these germ-cell marks
may act postfertilization to enact
long-term changes in offspring behavior or physiology. In this study,
through zygote microinjection
of nine specific sperm miRs previously
identified in our paternal stress mouse model, we demonstrate that sperm
miRs function
to reduce maternal mRNA stores in early
zygotes, ultimately reprogramming gene expression in the offspring
hypothalamus and
recapitulating the offspring stress
dysregulation phenotype.
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